COMPOUNDING INSTRUCTIONS

The following instructions are meant for Pharmacists to show how best to compound DermaZinc® products.

Please note that the steroids are used in a micronized (powder) form.

Select a DermaZinc® Product
You can purchase any of our DermaZinc® Spray's / Cream's / Shampoo's for the purpose of compounding.
Select a Steroid
DermaZinc® can be compounded with Micronized Betamethasone Dipropionate or with Clobetasol Propionate.
Provide Instructions for your patients
Once compounded, the instructions on the packaging change. It is important to be sure you tell your patients the most accurate instructions for how best to take the now compounded DermaZinc® product.

DermaZinc® Compounding Instructions - Betamethasone Dipropionate

Spray: Add 64mg of Micronized Betamethasone Dipropionate USP directly to a 4 oz. (120ml) bottle of DermaZinc® Spray (wt = 100gm), estimated 6 months stability when compounded. Instruct patient to shake well before using & keep away from extreme heat.

Cream: Levigate 77mg of Micronized Betamethasone Dipropionate USP with a small amount of Glycerin or Mineral Oil and mix into a 4 oz. (120gm) jar of DermaZinc® Cream, or add 6 cc of stock solution (see below) to 120 gm jar of DermaZinc® Cream. Estimated 6 months stability when compounded.

Shampoo: Whisk 144mg of Micronized Betamethasone Dipropionate USP into a 8 oz. (240ml) bottle of DermaZinc® Shampoo, or add 11cc of stock solution (see below) to 240ml bottle of DermaZinc® Shampoo. Estimated 6 months stability when compounded. Instruct patient to shake well before each use.

FAQ's with Betamethasone Dipropionate

If your balance can not weigh small amounts, dissolve 640mg of Micronized Betamethasone Dipropionate USP into 50cc of 99% isopropyl alcohol 12.8mg stock solution =1cc. Add 5cc of this to 120cc DermaZinc®, or 6cc to DermaZinc® Cream (120gm) or 11cc to DermaZinc® Shampoo (240ml). A better way to treat the scalp is to use DermaZinc® Shampoo in conjunction with DermaZinc® w/ Betamethasone Dipropionate USP product using the dropper tip. The rational is that the Rx Shampoo is washed out quickly whereas you massage in the drops. Estimated stability once compounded is six months. Estimated stock solution stability is one year from date of compounding.

Each gram of finished product contains 0.64mg Micronized Betamethasone Dipropionate USP is equivalent to 0.5mg of Micronized Betamethasone USP w/w.

Spray – 64 mg of Micronized Betamethasone to 4 oz DermaZinc Spray/Drops. Cream – 77 mg of Micronized Betamethasone to 4 oz DermaZinc Cream.

DermaZinc® Compounding Instructions - Clobetasol Propionate

Spray: Add 50mg of Micronized Clobetasol Propionate USP directly to a 4 oz. (120ml) bottle of DermaZinc® Spray (wt = 100gm), estimated 6 months stability when compounded. Instruct patient to shake well before using & keep away from extreme heat.

Cream: Levigate 60mg of Micronized Clobetasol Propionate USP with a small amount of Glycerin or Mineral Oil and mix into a 4 oz. (120gm) jar of DermaZinc® Cream, or add 6 cc of stock solution (see below) to 120 gm jar of DermaZinc® Cream. Estimated 6 months stability when compounded.

Shampoo: Whisk 120mg of Micronized Clobetasol Propionate USP into an 8 oz. (240ml) bottle of DermaZinc® Shampoo, or add 12cc of stock solution (see below) to 240ml bottle of DermaZinc® Shampoo. Estimated 6 months stability when compounded. Instruct patient to shake well before each use.

FAQ's with Clobetasol Propionate

If your balance can not weigh small amounts, dissolve 1 gram of Micronized Clobetasol Propionate USP into 100cc of 99% isopropyl alcohol 10mg stock solution =1cc. Add 5cc of this to 120cc DermaZinc® Spray, or 6cc to DermaZinc® Cream (120gm) or 12cc to DermaZinc® Shampoo (240ml). A better way to treat the scalp is to use DermaZinc® Shampoo in conjunction with DermaZinc® w/ Clobetasol Propionate USP product using the dropper tip. The rational is that the Rx Shampoo is washed out quickly whereas you massage in the drops. Estimated stability once compounded is six months. Estimated stock solution stability is one year from date of compounding.

50mg of Clobetasol Propionate USP in 120cc of DermaZinc® solution is equivalent to 0.05% w/w solutions similar to clobetasol lotion. 120cc of DermaZinc® solution weighs approximately 100gm.

Spray – 50 mg of Micronized Clobetasol to 4 oz DermaZinc Spray/Drops. Cream – 77 mg of Micronized Betamethasone to 4 oz DermaZinc Cream.

COMPOUNDING INSTRUCTIONS

Select a DermaZinc® Product

Select a Steroid

Provide Instructions for your patients

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